Comparative studies on peptides representing the so-called tachykinin-like region of the Alzheimer Aβ peptide [Aβ(25–35)]

نویسندگان

  • Omar M. A. EL-AGNAF
  • G. Brent IRVINE
  • Geraldine FITZPATRICK
  • David J. S. GUTHRIE
چکیده

In an attempt to answer the question of whether or not the socalled tachykinin-like region of the Alzheimer β-amyloid protein [Aβ(25–35)] can act as a tachykinin, the sequences Aβ(25–35), Aβ(25–35)amide and their norleucine-35 and phenylalanine-31 analogues were synthesized. These peptides were examined with ligand binding studies, electron microscopy, CD and NMR. In all cases some differences were found between the Aβ(25–35)

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تاریخ انتشار 1998